In the context of the Pancreatic Cancer Awareness Month, we encourage everyone to stay informed about the latest pancreatic cancer treatment developments and support research efforts. By uniting in our efforts, we can make significant strides in addressing this challenging disease. 


The challenge of late diagnosis in pancreatic cancer 

A significant problem with pancreatic cancer (PC) is its late detection. Often, when patients exhibit symptoms, the disease is already in an advanced stage. At this point of diagnosis, approximately 80% of patients already have micrometastases, significantly diminishing their survival prospects. This pattern of late detection is a critical factor contributing to the overall poor prognosis associated with pancreatic cancer. It underscores the urgent need for early diagnostic methods and highlights the crucial role of ongoing research and innovation in this field. 

The following study highlights significant progress in pancreatic cancer treatment, as recommended by leading oncological scientific societies such as ESMO, NCCN, ASCO, NICE, and SEOM over the past five years. Key points include the late diagnosis and poor prognosis of pancreatic cancer, with a focus on treatment advances like combined FOLFIRINOX therapy and gemcitabine. The role of molecular therapies in extending survival, especially in patients with specific gene mutations, is also emphasized, along with the challenges posed by the heterogeneity of molecular disorders in pancreatic cancer. 


Evolving treatment protocols for pancreatic cancer 

In recent years, there has been a paradigm shift in the treatment strategies for pancreatic cancer. Personalized medicine has emerged as a focal point, with treatment regimens like combined FOLFIRINOX being recommended for patients in better health and gemcitabine for those more fragile. This approach represents a significant advancement in managing this complex disease, tailoring treatments to individual patient needs and conditions. 

Targeted treatment strategy

Targeted treatment strategy in metastatic pancreatic cancer. 


The role of molecular profiling in the tratment of pancreatic cancer

Molecular profiling of tumors has become a cornerstone in the treatment of pancreatic cancer. This innovative approach facilitates more targeted therapies, particularly for patients harboring specific genetic mutations. Such personalized treatment strategies have the potential to not only extend survival but also improve the quality of life for patients with pancreatic cancer.  

In light of the complex nature of pancreatic cancer, the search for new methods of early diagnosis is essential. Bioinformatics tools have shown promise in this area, aiding in identifying new biomarkers and offering insights into the disease’s progression. For example, studies have utilized these tools for early detection and to explore the biological behavior and molecular mechanisms of pancreatic cancer, highlighting their potential to improve diagnosis and treatment strategies. 

The battle against metastatic pancreatic cancer is far from over. Still, as the scientific community continues to unravel the molecular complexities of this disease, the future is increasingly promising for developing more effective and targeted therapies. Including biomarkers in this process is pivotal, enhancing the precision and effectiveness of these treatments. 


Read the full article here.

Pajewska M, et al. (2023) Management of Metastatic Pancreatic Cancer-Comparison of Global Guidelines over the Last 5 Years. Cancers (Basel). 2023 Sep 2;15(17):4400. doi: 10.3390/cancers15174400.