OUR BIOMARKERS

Liver Fat & Iron concentration
  • Description

    QUIBIM has developed a VIRTUAL BIOPSY tool that analyzes MR volume datasets to provide a simultaneous quantification of iron, fat and water concentration for evaluating hepatic diseases, improving the quality of the radiologist’s reports and the accuracy of their diagnoses. The simultaneous quantification is done with the use of mathematical modelling of the MR signal without confounding effects and taking into consideration the heterogeneous distribution of deposits. Also, parametric images from the whole liver parenchyma are provided.

  • Application

    The measurement of liver fat and iron based on MR imaging allows to reveal tissue abnormalities before any symptoms appear, providing a reliable method to monitor the effects of a treatment.

    The most relevant values allow discriminating, with high accuracy, among the different grades of liver steatosis.

    • Proton density fat fraction (PDFF)
    • Iron related R2*

    This tool is useful for the diagnosis and follow-up of diffuse liver disorders.

  • Diseases
    • Chronic liver diseases
    • Cirrhosis
    • Fibrosis
    • Steatohepatitis
    • Hemochromatosis
    • Inflammatory activity
  • Performance
  • References

    França, M., Martí-Bonmatí, L., Porto, G., Silva, S., Guimaräes, S. and Alberich-Bayarri, Á. (2017). Tissue iron quantification in chronic liver diseases using MRI shows a relationship between iron accumulation in liver, spleen, and bone marrow. Clinical Radiology.

    França, M., Alberich-Bayarri, Á. and Martí-Bonmatí, L. (2017). Accurate simultaneous quantification of liver steatosis and iron overload in diffuse liver diseases with MRI. Abdominal Radiology, 42(5), pp. 1434-1443.

    Martí-Bonmatí, L., Alberich-Bayarri, Á. and Sánchez-González, J. (2012). Overload hepatitides: quanti-qualitative analysis. Abdom. Imaging. 37(2): 180-7.

    Erturk, SM., Alberich-Bayarri, Á., Herrmann, KA., Martí-Bonmatí, L. and Ros, PR. (2009). Use of 3.0-T MR imaging for evaluation of the abdomen. Radiographics. 29(6): 1547-63.

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