Oncology Imaging Biomarkers
Imaging biomarkers define objective quantitative characteristics extracted from medical images that are related to normal biological processes, clinical endpoints in diseases, or the response to treatment.
In order to develop an imaging biomarker, it is necessary to carry out a series of steps to validate its relation with the reality studied and to check its clinical and technical validity. As we published in 2012 (https://www.ncbi.nlm.nih.gov/pubmed/21733539) and later adopted by the European Society of Radiology (ESR) (https://www.ncbi.nlm.nih.gov/pubmed/23397519), these steps allow for an efficient way of adoption of imaging biomarkers either in clinical routine or clinical trials. This process includes defining tests for the concepts and mechanisms; obtaining standardized and optimized anatomic, functional, and molecular images; analyzing the data with computer models; displaying data appropriately; obtaining the appropriate statistic measures; and conducting tests on the principle, efficacy, and effectiveness. Although important advances are being developed nowadays in the field of image processing algorithms for the extraction of quantitative information from images, the integration of this information in clinical routine requires the existence of validated biomarkers, according to specific protocols for their analysis, in terms of the processing algorithms needed, the models applied and the way the results are generated.
All these topics will be addressed in the upcoming Summer School that we are organising from the 25th to 29th of next July in Valencia under the umbrella of the European Institute for Biomedical Imaging Research (EIBIR). In case you are interested please register to the course and you will enjoy an unforgettable week in Valencia.