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Ines Perea, Strategic Advisor at QUIBIM

Quibim’s Strategic Advisor Inés Perea discusses the radical disruptions that quantitative imaging analysis can provide to cancer research

Quibim’s Strategic Advisor Inés Perea discusses the radical disruptions that quantitative imaging analysis can provide to cancer research amongst other areas

Inés Perea is a Doctor that graduated with honors in the Pharmacy and Executive Business Program by Instituto de Empresa of Madrid. Mrs. Perea has extensive and versatile experience spanning more than 20 years in the Pharmaceutical industry working within different roles within the Medical, Access and Commercial (Marketing, Sales, Strategic Planning) areas and international experience in Global and regional teams. Her main area of expertise is oncology and biologics where she has been involved in the strategic planning and commercialization of more than 10 drugs/indications, most of them linked to some form of biomarker diagnosis.

How did you come to know QUIBIM before becoming their strategic advisor?

I was in contact with founder and CEO, Angel Bayarri months prior to my start with Quibim. A mutual friend of ours, a director of a large genetics biomarker laboratory in Spain was working specifically on oncology genetic biomarker testing and I would get involved with his organization in the arenas of strategic value and development, as those are two of my core competencies. I was involved in the development and strategic value of genetic/biologic biomarkers in clinical trials in oncology. It was back in the 90’s when biomarkers were a thing of science fiction. Well, he introduced me to Angel and I really thought he had a fantastic idea when it came to implementation of 3-d imaging biomarkers and using algorithms to quantitatively analyze tumors. Once I learned about Quibim’s technology, I knew that the growth could be exponential if he partnered with strategic partners.

Your field of expertise is Oncology. The Quantitative Medical Imaging field has evolved significantly but we still use RECIST criteria for evaluation of treatment responses, what do you think is the main reason for this? Standardization?

This is the foundation for therapeutic trials. It is a standard when examining patients, however, it has some practical limitations. For example, with the latest breakthrough area in oncology research, immunotherapy, many immuno-oncology drugs are known to cause fluctuations in tumor size, which when analyzed simply with RECIST criteria, would appear as an increase to the tumor size, but it is now understood that tumor fluctuations occur regularly during immunotherapy treatments, often causing the tumor to grow prior to cell DE progression, which is in fact a good sign that would be captured with RECIST criteria well after the fact. In those cases, RECIST does not allow for factoring in the context of the holistic viewpoint that quantitative digital image analysis would facilitate.

What therapeutic indications are best served by incorporating quantitative imaging analysis into clinical research trials?

There is a very simple answer to this question: any therapeutic indication where standardized radiological assessments are a primary or secondary safety or efficacy endpoint of a study. This includes solid tumors, liver diseases, brain diseases, lung diseases, and many others.

Let’s discuss costs. Quantitative imaging analysis sounds expensive. However, automation and extraction of biomarkers as soon as a hospital acquires and uploads images related to a clinical trial can and do have a macroeconomic effect of lowering costs, therefore long-term costs decrease. What do you respond with when someone brings up this objection?

You are right, it is a tremendous cost saver from a macroeconomic point of view. What will continue to help this cause are national health systems, private funding, insurers, and other payers to see the long-term cost savings and efficiencies that quantitative imaging analysis facilitates. Essentially, we need to get quantitative image analysis included in the health system reimbursement system much like traditional biomarkers of a decade ago. As a matter of fact, it took health systems quite a bit of time to include standard biomarkers that we have all grown accustomed to, included on their reimbursement schedules. While it essentially all boils down to payers and health authorities, us researchers and technology pioneers need to continue to prove medium and long-term efficiencies and validate it with radiologists, clinicians and imaging researchers. Once we are able to do that effectively, the market will adjust accordingly, it always does.

The value seems to be in real-time results that can help in both safety and efficacy outcomes. Please expand further on this thought.

Real time results are everything if you really think about it. The main benefit is obviously how this technology facilitates the real time patient care capabilities of healthcare practitioners. Safety and efficacy instant results from treatments are critical when analyzing real time clinical research data. Imaging biomarkers can and will play a tremendous role in improving patient standard of care, and ultimately can make a real impact on disease outcomes.

by: Dan Sfera, also available at: https://medium.com/quibim/quibims-strategic-advisor-in%C3%A9s-perea-discusses-the-radical-disruptions-that-quantitative-imaging-54cef3a3e082

quibim_imaging-biomarkers_funding round

QUIBIM cierra una ronda de inversión de 550.000€

La financiación permitirá a la empresa mejorar su plataforma de análisis de imágenes médicas y su comercialización

 

Valencia, 27 de diciembre de 2016. QUIBIM S.L, empresa biotecnológica de análisis avanzado de imágenes médicas, ha anunciado el cierre de su primera ronda de financiación por un valor de 550.000 euros de la mano de Tech Transfer UPV, AYCE Capital, Bioinfogate y los propios promotores de la compañía.

Se trata de la primera empresa de España en cerrar una ronda de inversión con un fondo de transferencia tecnológica asociado a una Universidad Pública: TechTransfer UPV, cuya finalidad es la creación y consolidación de empresas con elevado potencial de crecimiento, procedentes del ámbito investigador. Esta ronda de inversión permitirá a la empresa acelerar el desarrollo y comercialización del producto para seguir creciendo como compañía referente en la gestión y procesado de imagen médica en el ámbito hospitalario e industria farmacéutica,  promoviendo así, su consolidación nacional y expansión internacional.

Con sede en Valencia, la empresa, que es Spin-Off del Instituto de Investigación Sanitaria La Fe, fue fundada en 2012 e impulsada por Ángel Alberich-Bayarri y el Dr. Luis Martí Bonmatí tras una larga trayectoria de investigación y desarrollo. Ángel Alberich-Bayarri es Dr. Ingeniero Biomédico por la Universidad Politécnica de Valencia y es el CEO de QUIBIM. Luis Martí-Bonmatí es un radiólogo de reconocido prestigio internacional y es el Director del Área Clínica de Imagen Médica del Hospital Universitario y Politécnico La Fe de Valencia.

El modelo de negocio de QUIBIM (Quantitative Imaging Biomarkers in Medicine) se  basa  en  la  extracción  de  información cuantitativa de las imágenes médicas radiológicas y de medicina nuclear mediante técnicas originales y avanzadas de procesamiento  computacional. Para Alberich-Bayarri, QUIBIM tiene por objetivo: “mejorar  los  procesos  de  diagnóstico  de  enfermedades  con  alta  incidencia y  evaluar  adecuadamente  los  cambios  que  producen  los tratamientos farmacológicos en el organismo, para  aportar  así,  diagnósticos  mucho  más certeros y precoces, complementando de manera cuantitativa y medible la valoración cualitativa que se realiza a partir del ojo del radiólogo en la Medicina actual”.

QUIBIM fue una de las start-ups valencianas seleccionadas en la 3ª edición del programa Lanzadera, promovido por el Presidente de Mercadona, Juan Roig. El programa Lanzadera permitió impulsar a la empresa con formación y asesoramiento, así como con una financiación aproximada de 200.000€.

La startup ha desarrollado una plataforma de análisis de imágenes médicas en la nube, que puede instalarse en versiones privadas para hospitales y para compañías farmacéuticas que desarrollen ensayos clínicos. A partir de imágenes de rayos X, Ecografía , TAC, Resonancia Magnética o PET, QUIBIM es capaz de aplicar avanzados algoritmos de análisis que incluyen metodologías basadas en procesamiento por GPU (unidades de procesamiento gráfico), Machine Learning o Big Data. El software de QUIBIM permite aportar una mayor información en los diagnósticos y poder evaluar de forma temprana la respuesta a los tratamientos farmacológicos.

La compañía comercializa diferentes modelos de análisis para hospitales, empresas farmacéuticas y radiólogos. Para 2017 mantiene un presupuesto de ventas de 500.000€ de los cuales a fecha de hoy tiene ya comprometido el 30%.

Según afirma Ángel Alberich-Bayarri: “Estamos muy satisfechos con el cierre de esta ronda porque supone un gran impulso para nosotros, la financiación nos permitirá mejorar nuestra plataforma de análisis y su comercialización. Además, los inversores no aportan únicamente el capital, sino también su experiencia en el sector biotecnológico, lo que nos es de especial relevancia en esta fase de crecimiento”.

Por su parte, Pedro de Álava, director del Fondo Tech Transfer UPV, ha destacado que “la imagen médica está revolucionando la medicina al aportar soluciones personalizadas, precisas y predictivas del comportamiento de las enfermedades. Y el proyecto de QUIBIM reúne talento, disciplina técnica y escalabilidad, lo que genera un amplio valor para hospitales, empresas farmacéuticas y pacientes”.

El Dr. José Mateos, especialista en diagnóstico por imagen y director médico de Imagen Ensayos Clínicos S.L (IEC) empresa líder en la gestión de imagen en ensayos clínicos con más de 10 años de experiencia aportando valor a los estudios promocionados por los principales laboratorios farmacéuticos y CROs a nivel internacional, ha explicado “Durante los últimos 3 años estamos creciendo y consolidando nuestra posición a nivel local y nacional. La inversión actual de nuestra compañía en Quibim y las sinergias ya establecidas hace unos meses entre ambas empresas nos situarán como referentes indispensables en ensayos clínicos a nivel nacional e internacional”.

El Dr Jose Prous, Director Ejecutivo de BioInfoGate y cofundador del Prous Institute for Biomedical Research subrayó: “Los biomarcadores de imagen constituyen un elemento clave para optimizar el descubrimiento, desarrolllo y aplicación clínica de fármacos más eficaces y seguros. En la nueva era de la medicina de precisión, los innovadores métodos analíticos desarrollados por QUIBIM, permitirán optimizar el abordaje terapéutico de múltiples enfermedades.”

Sobre Tech Transfer UPV, f.c.r

Tech Transfer UPV es el primer fondo de transferencia de tecnología impulsado dentro del sistema universitario español que apuesta por proyectos de transferencia de tecnología y emprendimiento generados en la Universitat Politècnica de València para acompañarlos en su salida al mercado.

Tras este primer cierre de inversión, dispone de un patrimonio de 3,9 millones de euros. El Fondo está participado por 28 empresarios y profesionales valencianos y de Castellón de diferentes sectores que, además de invertir, participan como validadores de los proyectos. Entre ellos, el Instituto Valenciano de Finanzas, Caixa Popular Productos Citrosol, Air Nostrum, Grupo IVI, Multiscan, ACAL, Arca Telecom, S2 Grupo, Miarco, La Unión Alcoyana Seguros, Nero Family, Blast of partners, Tecnopaking, Vik Consultoría o Ca&CCA ingeniería.

Sobre AYCE Capital e Imagen en Ensayos Clínicos S.L.

AYCE Capital es una gestora friendly Business Angels de Barcelona que trabaja con proyectos de sectores muy distintos: servicios, healthcare, industrial, retail, cultura, agro-alimentario, TIC…

IEC es inversor en QUIBIM de la mano de AYCE Capital

Sobre Bioinfogate

 

BIOINFOGATE (www.bioinfogate.com) es una spin-off del Prous Institute for Biomedical Research (www.prousresearch.com) , con sede en Barcelona. La empresa ha sido creada con el objetivo de dinamizar la investigación en biomedicina y tecnologías médicas mediante el uso intensivo de metodologías de “Data Science” (big data) y bases de datos especializadas.

Las soluciones desarrolladas por el grupo Prous han sido utilizadas con éxito, durante los últimos 50 años, por científicos de todo el mundo en el descubrimiento de nuevos fármacos. Primero desde Prous Science (adquirida por Thomson Reuters en 2007) empresa líder mundial en el desarrollo de bases de datos (Integrity) y publicaciones de química médica (Drug of the Future) y posteriormente desde el Prous Institute for Biomedical Research mediante el desarrollo de sistemas expertos en predicción de seguridad y toxicidad de fármacos (Symmetry) y la invención de nuevas moléculas para el tratamiento de enfermedades neurodegenerativas, cáncer y diabetes.

Los productos del grupo Prous se utilizan diariamente en todas las  organizaciones relacionadas con las ciencias de la salud incluyendo industrias farmacéuticas y de biotecnología, centros de investigación públicas y privados y agencias reguladoras como la U.S. Food and Drug Adminstration (FDA).

Complementariamente a los desarrollos propios, Bioinfogate invierte en proyectos emergentes que se alinean con nuestro negocio principal en ciencias de la vida y análisis de datos.

quibim_imaging-biomarkers_funding round

QUIBIM closes a seed funding round of €550,000

The funding will allow the company to improve the platform for medical image analysis and work in marketing and sales strategy

 

Valencia, 27 December 2016. QUIBIM SL is a biotechnology company dedicated to advanced medical image analysis that has announced the closing of its first round of funding worth 550,000 euros shared by Tech Transfer UPV, AYCE Capital, and Bioinfogate, besides the own promoters of the company.

It is the first company in Spain to close an investment round with a technology transfer fund associated with a Public University: TechTransfer UPV, whose purpose is the creation and consolidation of companies with high potential for growth, from the research field. This round of investment will enable the company to accelerate the development and commercialization of the product to continue to grow as a leading company in the management and processing of medical images for hospitals and the pharmaceutical industry, thus promoting its national consolidation and international expansion.

Based in Valencia (SPAIN), the company, which is Spin-Off of the Institute of Health Research La Fe, was founded in 2012 and promoted by Angel Alberich-Bayarri and Dr. Luis Martí Bonmatí after a long history of research and development. Ángel Alberich-Bayarri is PhD in Biomedical Engineering from the Polytechnic University of Valencia and is the CEO of QUIBIM. Luis Martí-Bonmatí is an international Key Opinion Leader in Radiology and is the Director of the Clinical Area of ​​Medical Image of the Hospital Universitario y Politécnico La Fe in Valencia.

The business model of QUIBIM (Quantitative Imaging Biomarkers in Medicine) is based on the extraction of quantitative information of medical images in radiology and nuclear medicine through original and advanced computer processing techniques. For Alberich-Bayarri, QUIBIM aims to: “improve the diagnostic processes of diseases with high incidence and adequately evaluate the changes that produce the pharmacological treatments in the organism, to contribute to much more accurate and early diagnoses, complementing in a quantitative and measurable way the qualitative valuation that is performed from the eye of the radiologist in today Medicine”.

QUIBIM was one of the start-ups valencianas selected in the 3rd edition of the acceleration program, promoted by the President of Mercadona, Juan Roig. The program allowed to boost the company with training and mentoring, as well as with a funding of approximately € 200,000.

The startup has developed a platform for medical image analysis in the cloud, which can be installed in private versions for hospitals and pharmaceutical companies to develop clinical trials. By using X-ray images, Ecography, CT, MRI or PET scans, QUIBIM is able to apply advanced analysis algorithms including GPU-based (graphics processing units) processing, or Big Data and Machine Learning methodologies. The QUIBIM software allows to provide more information in the diagnoses and to be able to evaluate in an early way the response to the pharmacological treatments.

The company markets different analytical models for hospitals, pharmaceutical companies and radiologists. For 2017 maintains a sales budget of 500,000 € of which to date has already committed 30%.

According to Angel Alberich-Bayarri: “We are very satisfied with this funding round because it is a great boost for us, the financing will allow us to improve our analysis platform and its commercialization. In addition, investors do not only contribute capital, but also their experience in the biotechnology sector, which is of special relevance to us in this phase of growth”

Pedro de Álava, director of the Tech Transfer UPV Fund, stressed that “the medical images are revolutionizing medicine by providing personalized, accurate and predictive solutions to the behavior of diseases. And the QUIBIM project brings together talent, technical discipline and scalability, which generates a wide value for hospitals, pharmaceutical companies and patients.”

Dr. José Mateos, a specialist in image diagnosis and medical director of Imagen Ensayos Clínicos SL (IEC), a leading company in image management in clinical trials with more than 10 years of experience, adding value to the studies promoted by the main pharmaceutical laboratories and CROs at the international level, stated “During the last 3 years we are growing and consolidating our position at local and national level. The current investment of our company in Quibim and the synergies already established a few months ago between both companies will place us as indispensable references in clinical trials at national and international level.”

Dr Jose Prous, Executive Director of BioInfoGate and co-founder of the Prous Institute for Biomedical Research, emphasized: “Imaging biomarkers are a key element in optimizing the discovery, development and clinical application of more effective and safe drugs. In the new era of precision medicine, the innovative analytical methods developed by QUIBIM will allow optimizing the therapeutic approach to multiple diseases. “

About Tech Transfer UPV, fcr

Tech Transfer UPV is the first transfer fund of technology promoted within the Spanish university system that bets on projects of technology transfer and entrepreneurship generated at the Universitat Politècnica de València to accompany them on their way out to the market.

After this first investment closure, it has a net worth of 3.9 million euros. The Fund is represented by 28 Valencian and Castellón businessmen and professionals from different sectors who, in addition to investing, participate as validators of the projects. Among them, the Valencian Institute of Finance, Caixa Popular, Productos Citrosol, Air Nostrum, Grupo IVI, Multiscan, ACAL, Arca Telecom, S2 Group, Miarco, La Unión Alcoyana Seguros, Nero Family, Blast of partners, Tecnopaking, Vik Consulting or Ca & CCA engineering.

About AYCE Capital e Imagen en Ensayos Clínicos SL

AYCE Capital is a friendly business angels manager from Barcelona who works with projects from very different sectors: services, healthcare, industrial, retail, culture, agri-food, ICT …

IEC is an investor in QUIBIM by the hand of AYCE Capital

About Bioinfogate

BIOINFOGATE ( www.bioinfogate.com ) is a spin-off of Prous Institute for Biomedical Research ( www.prousresearch.com ), based in Barcelona. The company has been created with the aim of boosting research in biomedicine and medical technologies through the intensive use of “Big Data” methodologies and specialized databases.

The solutions developed by the Prous group have been used successfully over the last 50 years by scientists worldwide in the discovery of new drugs. First from Prous Science (acquired by Thomson Reuters in 2007), the world’s leading developer of Integrity and Drug of the Future publications, and later from the Prous Institute for Biomedical Research through the development of systems Experts in safety prediction and drug toxicity (Symmetry) and the invention of new molecules for the treatment of neurodegenerative diseases, cancer and diabetes.

The products of the Prous group are used daily in all organizations related to the health sciences including biotechnology and pharmaceutical industries, public and private research centers and regulatory agencies such as the US Food and Drug Adminstration (FDA).

In addition to our own developments, Bioinfogate invests in emerging projects that are aligned with our core business in life sciences and data analysis.

Katherine Wilisch new member of QUIBIM team

A new ‘quibimer’ in our team

We are pleased to announce the incorporation of Mrs. Katherine Wilisch Ramírez as a new member of our team. Katherine is graduate in Biotechnology and Master in Human Genetics by the University of Valencia has recently joined to the QUIBIM team as General Coordination and CEO support. Katherine has a remarkable experience in the field of innovation and technology transfer. She previously was coordinator at the VIT salud network and at the Spanish Association of Scientific Entrepreneurs. She has collaborated in the organisation of more than 10 events related to health, technology and innovation. We welcome Katherine in our team and we wish her a brilliant future in QUIBIM. Enjoy this new experience of your life joining our great team and thank you for becoming a ‘quibimer’.

Katherine Wilisch new member of QUIBIM team

Katherine Wilisch new member of QUIBIM team