BIOMARKERS

ABOUT

WHAT IS AN IMAGING BIOMARKER?

An imaging biomarker is a parameter obtained objectively from medical images, which represents and quantifies a tissue property (structural, functional or biological), extracted after applying computational models and signal processing to images in the space and time domains.

QUIBIM offers a head to toe imaging biomarkers solution. The development of each imaging biomarker involves a controlled step-by-step process, implemented by QUIBIM and adopted in 2013 by the European Society of Radiology (ESR) guidelines, to ensure accurate and consistent high quality measures.

We provide a comprehensive range of imaging biomarkers to professionals who want to distinguish themselves by choosing to offer an added value to diagnostic radiology, research and clinical trials:

Neuro

Disease:

  • Neurodegenerative (Amyotrophic Lateral Sclerosis, Parkinson, Alzheimer)
  • Multiple Sclerosis
  • Stroke
  • Psychiatric disorders
  • Traumatic Brain Injury

Biomarkers:

  • Gray matter volumetry
  • Cortical thickness
  • Lesions segmentation
  • Tractography
  • Myelin mapping
  • Iron concentration
  • CSF dynamics
  • Functional MRI
  • Quantitative PET

Modalities:

  • Magnetic Resonance Imaging (MRI)
  • Positron Emission Tomography (PET)

Bone

Trabecular bone 3D reconstruction from MRI

Disease:

  • Osteoporosis
  • Oncology

Biomarkers:

  • Morphometry analysis (trabecular thickness, trabecular spacing, trabecular number, 2D and 3D fractal dimension)
  • Mechanical analysis (mechanical resistance and elasticity)
  • Bone quality score

Modalities:

  • Magnetic Resonance Imaging (MRI)
  • Computed Tomography (CT)
  • Micro-Computed Tomography (μCT)

Oncology and Hematology

Disease:

  • Solid tumors: breast, prostate, rectum, lung, liver, brain, msk.
  • Multiple myeloma
  • Aggressive lymphoma

Biomarkers:

  • Cellularity – Diffusion (ADC, IVIM, DKI)
  • Angiogenesis – Pharmacokinetics
  • Oxygen mapping
  • Lesion burden
  • Tumor textures
  • Bone Marrow Infiltration
  • Multi-Parametric Analysis

Modalities:

  • Magnetic Resonance Imaging (MRI)
  • Computed Tomography (CT)
  • Positron Emission Tomography (PET)

Liver

Disease:

  • Steatohepatitis
  • Hemochromatosis
  • Fibrosis

Biomarkers:

  • Fat fraction
  • Iron concentration
  • Inflammatory activity
  • Diffusion
  • Textures

Modalities:

  • Magnetic Resonance Imaging (MRI)
  • Computed Tomography (CT)

Lung

Disease:

  • Emphysema
  • Chronic Obstructive Pulmonary Disease (COPD)
  • Fibrosis
  • Pulmonary hypertension

Biomarkers:

  • Lung parenchyma volume
  • Emphysema volume & distribution
  • Lobe volumes
  • Fractal dimension
  • Airway stenosis

Modalities:

  • Computed Tomography (CT)